Idiopathic thrombocytopenic purpura

DEFINITION

Patient asks to mbah dukun: "Mbah, my name is Painem, im from Belgia, i have a problem. my son's legs frequently bruising, red spots appear, these has been about 6 months, intermittent, sometimes accompanied by fever, DHF-like disease. Would you tell me what is that?

Mbah Dukun anwers:

ITP, primary immune thrombocytopenia (also called immune (idiopathic) thrombocytopenic purpura), is an autoimmune disease. In autoimmune diseases, the body mounts an immune attack toward one or more seemingly normal organ systems. In ITP, platelets are the target. They are marked as foreign by the immune system and eliminated in the spleen and sometimes, the liver. In addition to increased platelet destruction, some people with ITP also have impaired platelet production.

Chronic Myelogenous Leukemia

 Definition

Chronic Myelocytic leukemia (mieloid, mielogenous, granulocytic, CML) is a disease in which a cell in the bone marrow turn into malignant and produce a large number of granulocytes (a type of white blood cells) are abnormal . When this happens, infectious anemia, or bleeding easily occurs. CML seldom attack individuals under the age of 20 years, but the incidence increases with age.

CARDIORENAL SYNDROME

DEFINTION
There is no definite definition of the notion Cardiorenal Syndrome (CRS). The National Heart, Lung, and Blood Institute defines the circumstances in which therapy to relieve symptoms of congestive heart failure is limited by the decline in kidney function. More broadly described as a state of moderate or high renal dysfunction, which appears in heart failure patients during therapy. Some say the CRS is the linkage of heart and kidney with the burden of excess fluid in which patients become resistant to diuretic therapy.

Haemophilia part 2 (Diagnostic and therapy)

ANAMNESTIC

 Until now the family history is still the best way to do the first riddle of the cases of haemophilia, although there are 20-30% of cases of haemophilia, found X chromosome due to spontaneous mutation in the gene encoding F VIII / F IX. A boy - he allegedly suffered from haemophilia, if there is a history of recurrent bleeding (hemartrosis, hematoma) or a history of bleeding after trauma or stretching certain actions with or without family history.

Hemophilia part 1

Patient asks to Mbah Dukun Bagong: Mbah, i had a friend, he was died 2 months ago, he got bleeding after circumcised, is circumcised dangerous?
Mbah Dukun Bagong answers: "mmmm i see, circumcised is not dangerous, its "sunnah" God commanded Abraham to circumcise his son, Ishmael. However, there is condition, which person can't be able to circumcised, its called HEMOPHILLIA

Myasthenia Gravis

DEFINITION


When Mbah Dukun surving on internet, he gets message from Nilla Gustian. Nilla wants information about Myasthenia Gravis.

What is Myasthenia Gravis?
Myasthenia Gravis (MG) is a chronic, autoimmune disease that causes muscle weakness and excessive muscle fatigue. The name comes from Greek and Latin words meaning "grave muscle weakness." But most cases of MG are not as "grave" as the name implies.
The disease can vary in severity and distribution of weakness between individuals, and in any one patient the symptoms fluctuate with relapses and remissions. MG can resolve spontaneously, but for most patients MG persists for life. It can be life threatening, but 90% of patients become symptom-free with modern treatments.
MG produces progressive weakness and fatigue and sporadic abnormal in skeletal muscles, which get worse after exercise and repetition of movement, but can be corrected with drugs antikholineterase.
Usually, this disorder that attacks the muscles controlled by cranial nerves (face, lips, tongue, neck, and throat) but can also attack other muscles.
MG followed the explosion of anger and periodic remissions that can not be predicted. Treatment was not known, but drug therapy can improve symptoms and allow patients to live relatively normal, except during the outburst occurred.
When the disease involves the respiratory system, it can endanger lives.

NEPHROTIC SYNDROME Part 2

COMPLICATIONS

Patient asks to Mbah Dukun : "Mbah, what are complications of NS?"

Mbah Dukun Bagong answers:



1. Nitrogen balance.

Massive proteinuria in the NS will cause a negative nitrogen balance. Decreased muscle mass is found but these symptoms are often found covered with new symptoms and edema anasarka looked after the edema disappeared. Loss of muscle mass by 10-20% of body mass (lean body mass) are not rare in NS.